You say you want to 3bet this 22 to set up a 5b jam. But you dont even know if the opponent will have (enough) 4bet blufs? In a 6max game this would normally be very optimistic to jam over somebody's 4bet when you don't know if the player 4bet blufs enough.
What would be your weakest hand here to 3b/5b jam for value? AQ+ and 99? Do you think he will 4bet call 66-88 and AJ?
it's different early in a hu match when you are running the guy over with 3bets. I expect his range that 4bets us the first time to be extremely air heavy.
In hu reg on reg it's pretty standard to virtually always get it in with 88+ and AQ+, expanding out from there to either wider for value or wider for bluff depending on how your opponent adjusts, but the default assumption the way the games currently play is that the first 4bet is very often weighted heavily towards bluffs in situations where you have 3bet them several times in a row and they haven't fought back. As players become more aware of this dynamic, this will change (some already have).