If it's 9654x and you're playing 2-7 TD, no
If it's O8, No, if it's badugi and it's a badugi, hell-yeah.
not as a 1cd anyway. If the pfr steals frequently I might play it for one draw, drawing 3 to 54, and only continue if he drew 3 also or I caught another wheel card. I'm not really a fan of drawing two to 654 because if you catch say a seven or a three you have improved your draw but you're open-ended and if you catch an eight you have a gutshot. So if I was thinking that I couldn't profitably play it as a 3cd in a particular situation I would probably just fold.